Key Findings And Study Abstracts
- 9 month study shows that capsaicin nasal spray significantly reduces nasal complaints while also demonstrating a good safety profile.
Read More - Study shows remarkable effects of capsaicin for allergic rhinitis patients-the total effective rate was 89%.
Read More - 2 year study demonstrates the consistent therapeutic effect of capsaicin among cluster headache sufferers.
Read More - Study shows that capsaicin significantly reduced overall nasal symptoms, rhinorrhea and nasal blockage.
Read More - Majority of hyperactive rhinitis patients treated with intranasal capsaicin showed a significant reduction in symptoms without significant side effects.
Read More - Scientific review suggests that capsaicin may have the largest body of scientific evidence and clinical trial support of any topical agent for the treatment of cluster headache.
Read More - Intranasal capsaicin relieved the clinical symptoms of allergic rhinitis and remarkably reduced the level of Substance P in the nasal secretions.
Read More - Capsaicin improved predominate symptoms (nasal congestion, hypersecretion, sneezing) by 62-72%, offering a promising new option for treatment of hyperreactive rhinopathy.
Read More - Both episodic and chronic cluster headache patients treated with intranasal capsaicin on the same side where the attacks occurred showed significant improvement.
Read More - Study shows intranasal capsaicin to significantly reduce pain among perennial rhinitis sufferers.
Read More - Vasomotor rhinitis patients treated with capsaicin showed significant improvement in symptoms. These positive results continued throughout the 6 month treatment period and were accompanied by an improvement in nasal tissue health.
Read More - Capsaicin significantly reduced symptoms in chronic rhinitis patients with no significant side effects.
Read More - Nasal obstruction and nasal secretion was significantly reduced by intranasal capsaicin.
Read More - Scientific review shows that the efficacy of repeated intranasal capsaicin application has been established in several randomized controlled trials, offering patients with idiopathic rhinitis a new treatment option.
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Specific Studies
Below are some of the specific studies that are available on capsaicin’s mechanism of action:
- Fang, S., Shen, C. (1998). Neuropeptide innervation and neuroendocrine cells in allergic rhinitis and chronic hypertrophic rhinitis. Clinical & Experimental Allergy, Volume 28, Number 2, February, pp. 228-232(5)
- Fusco, B.M., Alessandri, M. (1992). Analgesic Effect of Capsaicin in Idiopathic Trigeminal Neuralgia. Anesth Analg. 74:375-377
- Fusco, B.M., Barzoi, G., Agrò, F. (2003). Repeated intranasal capsaicin applications to treat chronic migraine. British Journal of Anesthesia, Vol. 90, No. 6 812
- Fusco, B. M., Fiore, G., Gallo, F., Martelletti, P., Giacovazzo, M. (2005). Capsaicin-Sensitive” Sensory Neurons in Cluster Headache: Pathophysiological Aspects and Therapeutic Indication. Headache: The Journal of Head and Face Pain. Volume 34 Issue 3, Pages 132 – 137
- Kuhn FA, Gonzalez S, Rodriguez M, Siller CC, Zachariou V, Goldstein BD. (1997). Capsaicin’s effect on rat nasal mucosa substance P release: experimental basis for vasomotor rhinitis treatment. Am J Rhinol. Jul-Aug; 11(4):313-6.
- Seki N, Shirasaki H, Kikuchi M, Himi T., (2007). Capsaicin induces the production of IL-6 in human upper respiratory epithelial cells. Life Sci. Apr 3; 80(17):1592-7. Epub 2007 Jan 27.
- Valencia M, Randazzo L., (1992). Substance P: immuno-allergic implications. Allergol Immunopathol (Madr). Jan-Feb; 20(1):3-8.
- Yokota E, Kuyama S, Ogawa M, Kamei C., (2008). Substance P is involved in the effect of histamine H3 receptor agonist, Sch 50971 on nasal allergic symptoms in mice. Int Immunopharmacol. Aug;8(8):1083-8. Epub 2008 Apr 28.
- Zhang F, Han D, Zhu X. (1999). Immunohistochemical and pathological study of capsaicin in the treatment of rabbit animal model with allergic rhinitis. Zhonghua Er Bi Yan Hou Ke Za Zhi. Aug; 34(4):229-31.
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