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| How Does Buster Work? |
Well, the short answer is, quickly and effectively – and you can actually feel it relieving your sinuses from the very first spray.
But for those of you who might want a more scientific answer…
Each Sinus Buster formula is made with natural capsaicin extract to relieve congestion, inflammation and pain. An enormous amount of scientific research has been conducted to better understand how capsaicin works. While the actual mechanism by which this happens is still not fully understood, there are several discoveries that do provide valuable insights into capsaicin’s amazing effect on the body:
1) Capsaicin desensitizes the mucus membrane and blocks Substance P, the chemical messenger that relays pain signals to the brain
Your nose has a very high concentration of nerve cells that are constantly sending information like smells and “how to breathe" to your brain. The most important of these nerves is called the Trigeminal Nerve and it runs through your head, temple and sinus cavity. Substance P is the primary messenger molecule to your nerve cells and is the body’s main mechanism for producing swelling and pain along the trigeminal nerve and in the nasal and sinus cavities.
An increase in the production of Substance P can set off a cascade of reactions that leads to pain, inflammation and congestion. It may also cause swelling of the blood vessels in your nose. In response to this, the body’s natural defense is to increase
mucus secretions which can cause runny nose, sneezing and congestion. This can then lead to more pain and inflammation, which in turn increases Substance P driving
a “vicious” cycle. Sinus Buster with capsaicin interrupts this cycle by blocking Substance P, restoring
balance and thereby decreasing pain, congestion and inflammation.
2) Sinus Buster with capsaicin increases mucus secretions
We typically do not think that having a runny nose or sneezing is a good thing.
However, a normal increase in mucus flow is an important part of the body’s defense mechanism. It helps the body to flush out bacteria, unwanted debris and allergens from the nasal cavities, minimizing irritation and preventing infection.
3) Sinus Buster with capsaicin dilates constricted blood vessels that can cause headaches
Migraine, cluster and hangover headaches are classified as vascular headaches, which means that they all involve blood vessel constriction. While the blocking of Substance P plays a significant role in providing headache relief, the relaxing of constricted vessels may be another way in which capsaicin helps relieve headaches.
Below are some of the specific studies that are available on capsaicin’s mechanism
of action:
- Fang, S., Shen, C. (1998). Neuropeptide innervation and neuroendocrine cells in allergic rhinitis and chronic hypertrophic rhinitis. Clinical & Experimental Allergy, Volume 28, Number 2, February, pp. 228-232(5)
- Fusco, B.M., Alessandri, M. (1992). Analgesic Effect of Capsaicin in Idiopathic Trigeminal Neuralgia. Anesth Analg.
74:375-377
- Fusco, B.M., Barzoi, G., Agrò, F. (2003). Repeated intranasal capsaicin applications to treat chronic migraine. British
Journal of Anesthesia, Vol. 90, No. 6 812
- Fusco, B. M., Fiore, G., Gallo, F., Martelletti, P., Giacovazzo, M. (2005). Capsaicin-Sensitive” Sensory Neurons in Cluster Headache: Pathophysiological Aspects and Therapeutic Indication. Headache: The Journal of Head and Face Pain. Volume 34 Issue 3, Pages 132 – 137
- Kuhn FA, Gonzalez S, Rodriguez M, Siller CC, Zachariou V, Goldstein BD. (1997). Capsaicin’s effect on rat nasal mucosa substance P release: experimental basis for vasomotor rhinitis treatment. Am J Rhinol. Jul-Aug; 11(4):313-6.
- Seki N, Shirasaki H, Kikuchi M, Himi T., (2007). Capsaicin induces the production of IL-6 in human upper respiratory
epithelial cells. Life Sci. Apr 3; 80(17):1592-7. Epub 2007 Jan 27.
- Valencia M, Randazzo L., (1992). Substance P: immuno-allergic implications. Allergol Immunopathol (Madr).
Jan-Feb; 20(1):3-8.
- Yokota E, Kuyama S, Ogawa M, Kamei C., (2008). Substance P is involved in the effect of histamine H3 receptor agonist, Sch 50971 on nasal allergic symptoms in mice. Int Immunopharmacol. Aug;8(8):1083-8. Epub 2008 Apr 28.
- Zhang F, Han D, Zhu X. (1999). Immunohistochemical and pathological study of capsaicin in the treatment of rabbit animal model with allergic rhinitis. Zhonghua Er Bi Yan Hou Ke Za Zhi. Aug; 34(4):229-31.
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